Deiodinase Types 1 and 3 and Proinflammatory Cytokine Values May Discriminate Depressive Disorder Patients from Healthy Controls

Introduction: Depressive disorders are multifactorial diseases in that a variety of factors may play role their etiology, including inflammation and abnormalities the thyroid hormone (TH) metabolism levels. The purpose this study was to evaluate iodothyronine deiodinases (DIOs) DIO-interacting cytokines as possible biomarkers diagnosis depressive disorders. Methods: This enrolled 73 patients diagnosed with recurrent disorder (rDD) 54 controls. expressions DIO1, DIO2, DIO3, IL1B, IL6, TNFA, IFNG genes, encoding three types DIOs (1, 2, 3), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, were assessed using polymerase chain reaction blood cells an enzymatic immunoassay method serum. levels examined molecules between controls compared, correlations diagnostic values evaluated. Results: Lower DIO2 higher TNFA found compared protein concentrations DIO1 lower, while DIO3 higher, than Serum IL-1β, TNF-α also area under curve (AUC) proteins >0.7 for discriminating rDD from Conclusions: genes have estimation processes present We can cautiously claim pivotal cytokines, mainly IL-1β depression diagnosis, further studies suggested explain exact these larger samples more precise methods.